Under the joint development program with Merck, matuzumab has been investigated in Phase II clinical trials in indications such as metastatic colorectal cancer (mCRC), gastric cancer, and non-small cell lung cancer (NSCLC), where it did not meet its predefined clinical endpoints of activity.
Discovered by Merck, matuzumab is a recombinant, humanized, monoclonal antibody (MAb) against the human EGFR (epidermal growth factor receptor), which is associated in the development and progression of a number of human solid tumors.