In this test, both uncoated and Cerashield coated tube segments were exposed to daily challenges of one million colony forming units per ml of Pseudomonas aeruginosa in nutrient media broth. The broth was changed on a daily basis and fresh inocula of bacteria were added daily for 14 consecutive days. On days seven and 14, uncoated and coated tube segments were removed and evaluated for bacterial adhesion and biofilm growth.
The uncoated tube segments showed substantial bacterial adherence (over 500,000 colony forming units) and extensive biofilm coverage while the Cerashield treated segments showed no bacterial adherence and no biofilm formation.
Steven Porter, chairman and CEO of Ceragenix, said: “Given the emerging crisis in mutating bacteria and the resultant hospital derived infections, half of which come from implanted medical devices, a coating that can prevent bacterial colonization of such devices is both timely and critically important.”