The new data demonstrate that, Angiolix has unusually high accumulation in multiple solid tumor types, including breast and ovarian cancer. Angiolix interferes with binding of a proprietary marker known as lactadherin, which is produced by cancer cells and binds to an adhesion molecule specifically expressed on new blood vessels produced by tumors. Lactadherin is not expressed in normal tissues and therefore it is a suitable marker for tumor targeting.
Agamemnon Epenetos, Access’s chief scientific officer, Europe, said: “We believe this two-pronged attack could potentially inhibit the process of angiogenesis and also induce apoptosis, promoting cancer cell death. Based on this data, we are commencing additional studies where Angiolix is administered in combination with chemotherapy in multiple tumor types, including breast and ovarian cancers.”