The study investigated the effects of ALSE-100 on osteoblast and osteoclast cells in culture as well as in an organ culture system. ALSE-100 stimulated differentiation and mineralization to form bone nodules in culture and also inhibited bone resorption, osteoclast development and activity. These effects indicate that ALSE-100 could be useful in promoting bone healing.
Noel Cusack, senior vice president of preclinical development at Alseres, said: “We believe that this study, using a range of doses of one of our Rho inhibitor variants, ALSE-100, has demonstrated that our Rho inhibitor platform may provide potentially attractive therapeutic candidates for promoting bone healing.”