Pharmaceutical Business review

Abpro, NJCTTQ partner to develop multiple bispecific antibody therapies

Image: Abpro and NJCTTQ have partnered to develop multiple bispecific antibody therapies. Photo: courtesy of JOSHUA COLEMAN / Unsplash.

The collaboration leverages Abpro’s proprietary DiversImmuneTM antibody discovery platform.

Under  the  terms  of  the  agreement,  Abpro  is  eligible to  receive up  to  $4  billion,  including $60 million  in  near-term  R&D  funding, plus  potential  milestones  and  royalties.  Abpro  will  retain all   commercial rights  for  any  approved  molecules  in  geographies  outside  of  China and  Thailand, while NJCTTQ will retain rights in China. Abpro and NJCTTQ will collaborate globally to pursue pre-clinical and clinical development efforts and, ultimately, commercialization.

“This collaboration further validates  our  platform’s  unique ability  to  develop  best-in -class bispecific T-cell engagers, with significant potential to treat patients living with cancer,” said Ian Chan, executive chairman and co  -founder   of   Abpro.

“NJCTTQ   has substantial   clinical development  and  commercialization  expertise  that is  highly  complementary  to  our  immuno-oncology  development  platforms  as  we  focus  on  broadening  our  pipeline  and  expanding  our ability  to  treat  more  patients  globally.  Our  ex-China  commercial  rights  have  the  potential  to  2generate  significant  long-term  value  for  our  company.  We  intend  to  pursue  additional  similar  development collaborations that leverage our innovative technology platforms and programs that include commercial rights in key global markets.”

Abpro develops therapeutic candidates for immuno-oncology using two proprietary platforms – DiversImmune and  MultimabTM.  To  date,  the  DiversImmune platform  has  generatedantibodies  for  pharmaceutical  and  biotechnology  companies  against  more  than  300  unique targets.

Abpro’s MultimabTM  bispecific  platform  then  enables  the  assembly  of  these  antibodies  into  a  variety  of  bi-   and  multi-specific  antibody  formats,  tailored  to  each  program.  Abpro has leveraged the DiversImmune and MultimabTM platforms to develop a pipeline of seven novel immuno-oncology  therapeutic  candidates,  including  best-in -class  T-cell  engagers,  as  well  as programs in ophthalmology and autoimmunity

“This agreement is representative of NJCTTQ’s culture of innovation,” said Chunxia Zhu, vice general manager of NJCTTQ. “  Abpro brings deep scientific experience and technical expertise around bispecific  antibody  development  and  T-cell  engagement  to  this  partnership.  We  are delighted to be collaborating to pursue and advance exciting and novel therapies for patients.”

Source: Company Press Release