The affected lots of Piperacillin and Tazobactam for Injection, USP 40.5 grams may show precipitation / crystallization in IV bag or IV line after reconstitution, which results in local reactions such as phlebitis, renal impairment, end-organ embolism and ischemia, and/or vasculitis.
The precipitation of the drug may also not allow delivering a needed therapeutic dose of piperacillin and tazobactam to target infection.
The affected Piperacillin and Tazobactam for Injection, USP 40.5 grams lots include the product stating NDC number 60505-0773-00 and UPC 360505077304, which were packaged in 300 mL glass vials for reconstitution and distributed nationwide.