The studies found that Prozac and Seroxat users developed thinner bones than those who did not take the selective serotonin reuptake inhibitors, or SSRIs.
The drugs work by inhibiting the protein that transports serotonin, a neurotransmitter involved in sleep and depression, which has recently been discovered in bone as well.
Rsearchers led by Dr Elizabeth Haney, from Oregon Health and Sciences University, Portland, took hip and bone density readings of nearly 6,000 men aged 65 and older. The hip readings were 3.9% lower for the 160 men taking antidepressants, compared to those not taking any. Additionally, spine bone mineral density was 5.9% lower for SSRI users.
Commenting on the results, Dr Haney said, “because SSRI use is prevalent in the general population, our findings have a potentially important public health impact. If confirmed, people using SSRIs might be targeted for osteoporosis screening and preventive intervention.”