One of the significant risks associated with heart surgery is cognitive impairment. This can be identified a few days or weeks following the procedures and in many cases is not reversible.
Scientists from The University of Southern California, in collaboration with Proteome Systems, have shown that Proteome Systems' compounds, including EUK-207 in particular, potently prevent neuronal damage induced by oxygen and glucose deprivation followed by reoxygenation due to cartoid artery bypass graft (CABG).
This data significantly extends previous studies in which EUK-207 had been shown to prevent cognitive impairment in aging mice.
This new data from the University of Southern California significantly strengthens the case for EUK-207 as a neuroprotectant for a range of neurological conditions.
“This new data clearly supports our therapeutic strategy. We will aggressively develop EUK- 207 for the neurological consequences of CABG and, more generally, open heart surgeries, indications for which no effective treatments are currently available,” said Stephen Porges, chief executive of Proteome Systems.