Approximately 40 women who received radiotherapy following conservative breast cancer surgery were randomized to receive either Xclair cream (22 patients), or a cream containing a control vehicle (18 patients). They received Xclair during their radiation therapy and for three weeks after completion of radiation.
Patients treated with Xclair demonstrated a statistically significant improvement compared to controls in maximum severity of skin toxicity (p < 0.0001), burning within the radiation field (p = 0.039) and desquamation or shedding of outer skin layers (p = 0.02). No adverse events were observed or reported and none of the patients on the Xclair arm were required to stop radiotherapy as a consequence of the effects of their radiation dermatitis. The study authors concluded that Xclair cream is an effective treatment regimen for the prevention of radiation-induced skin reactions and promotion of symptomatic relief.