Forest Laboratories and Glenmark Pharmaceuticals, a subsidiary of Glenmark Pharmaceuticals India (GPL) have announced top-line results from a phase IIb dose range finding study of Oglemilast in patients with Chronic Obstructive Pulmonary Disease (COPD). Once-daily treatment with Oglemilast did not show a statistically meaningful increase from baseline compared to placebo in the primary endpoint trough FEV1, a measure of pulmonary function that is decreased in patients with COPD. Oglemilast was well-tolerated at all doses studied.
The study was a twelve week randomised, double-blind, placebo controlled, multi-center phase IIb study that evaluated the efficacy and safety of once-daily Oglemilast at doses of 200mcg, 400mcg and 800mcg in patients with moderate to very severe COPD. Patients were at least forty years of age with a history of ten or more pack-years of smoking. During the study period 428 patients
were randomised to receive one of three doses of Oglemilast (n=320) or placebo (n=108) and assessed at eight visits. The primary endpoint was defined as change from baseline in prebronchodilator (morning/trough) FEV1 at week 12.
Howard Solomon, chairman and chief executive officer of Forest Laboratories, said: “Oglemilast is an orally administered PDE 4 inhibitor, which we believe to be an important and novel therapeutic target for COPD. We are, of course, disappointed that Oglemilast has not been successful in this study. Oglemilast is still being studied for the treatment of asthma, with results expected during the first calendar quarter of 2010. We are considering together with Glenmark what further action would be useful or appropriate.”
Oglemilast is a potent and selective inhibitor of phosphodiesterase 4 (PDE4). Oglemilast is currently in development for the treatment of COPD and asthma. Forest Laboratories licensed US rights for oglemilast from Glenmark Pharmaceuticals.