Under the contract, Jacobs will provide engineering, procurement, project management, construction management and validation services.
The contract, which is initially for two years, has the option to be renewed for an additional two years.
Jacobs Engineering Group vice president Tom Quinn said with the renewal of the alliance partnership, the company will continue to deliver superior value to GSK.
"This is the continuation of a ten year working relationship between Jacobs and GSK in Singapore," Quinn added.
The financial details of the contract has not been disclosed.