Developed under the collaboration, SAR650984 is being evaluated as a potential treatment for a number of hematological (blood) tumors, including acute and chronic lymphocytic leukemia, acute and chronic myeloid leukemia, multiple myeloma and non-Hodgkin’s lymphoma.
Reportedly, in preclinical testing, SAR650984 has been found to be an effective anticancer agent. Of particular note, it has been found to have potent antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and apoptotic activity (achievement of programmed cell death).
SAR650984 is being assessed in a Phase I, dose-escalation trial to establish its maximum tolerated dose and dose-limiting toxicities. Patients with certain types of relapsed/refractory CD38+ hematological malignancies are eligible for enrollment, including B-cell non-Hodgkin’s lymphoma, multiple myeloma, acute myeloid leukemia, acute lymphoblastic leukemia, and chronic lymphocytic leukemia.
John Lambert, executive vice president and chief scientific officer, said: “ImmunoGen has extensive capabilities in the development and evaluation of antibodies – both for use as anticancer agents on their own as ‘naked antibodies’, like SAR650984, and as part of TAP compounds.
“SAR650984 killed cancer cells through three different mechanisms – ADCC, CDC, and apoptosis – in our preclinical models. We believe this compound may provide unique benefits in the treatment of a number of hematological malignancies.”
ImmunoGen is a biotechnology company that develops targeted antibody-based anticancer products.