Pharmaceutical Business review

Novartis secures FDA approval for larger dosage of MS drug Glatopa

The approval is for Glatopa 40mg/mL as a fully-substitutable, AP-rated generic version of Teva Pharmaceutical Industries’ three times-a-week Copaxone 40mg/mL therapy (glatiramer acetate injection).

Glatopa was approved by the FDA in April 2015 as a 20mg/ml one-time-daily multiple sclerosis (MS) therapy and had been the only generic glatiramer acetate product on the market for more than two years.

Sandoz CEO Richard Francis said: “The approval and launch of Glatopa 40 mg/mL reinforces our leadership in delivering complex, differentiated generic products.

“We look forward to bringing this product to patients and healthcare professionals and providing a full range of patient support services for Glatopa through GlatopaCare.”

Glatopa was developed by Sandoz under a collaboration agreement with Momenta Pharmaceuticals and is manufactured in the US.

Momenta Pharmaceuticals said Glatopa 40mg/mL comprises the same active ingredients, route of administration, strength, and dosage form as the referenced product.

The company said that Glatopa 40mg/mL will deliver identical clinical effect and safety profile as three times-a-week Copaxone 40mg/mL, which is often, prescribed as a first-line therapy in newly diagnosed MS patients.

Momenta Pharmaceuticals president and CEO Craig Wheeler said: “This approval further validates the strength of our physicochemical and biological characterization capabilities.

“We are very proud to once again be able to provide patients with relapsing-forms of MS with a cost effective, high-quality generic alternative treatment option.”


Image: Novartis headquarters in Basel, Switzerland. Photo: courtesy of Novartis AG.