The new coupling methods will greatly expand the technology’s applicability in the key drug discovery and life science research markets.
The three new coupling methods, for use with SoPRano ‘Build-Your-Own-Assay’ kits are Carboxyl coupling, CA2 (Charge Adsorption 2) methodology and Biotin-Direct (BD), which enables direct coupling of biotinylated proteins to gold nanoparticles.
The BD method has a particular benefit over standard streptavidin-biotin couplings in that the biotinylated proteins bind directly to the gold, without the need for streptavidin.
PharmaDiagnostics’ Biotin-Direct method now offers pharma and biotech companies a method that overcomes these issues, with the potential to improve the quality of early stage drug discovery.
Coupling of target proteins to SoPRano nanoparticles is the first step in assay development, and the three new coupling methods extend the range of proteins that can be coupled to SoPRano nanoparticles, thereby enabling broader application of the technology in pharmaceutical research.