Sera Laboratories has launched liver microsome products from over 12 species, including mouse, rabbit, monkey and chicken, and the researchers can choose from pure microsomes or S9 fractions, including animal liver cytosol.
In addition, Sera has announced that it would supply bespoke microsome products from other species or strains, as required.
Microsomes are a useful tool for investigating drugs metabolism such as enzyme inhibition, clearance and metabolite identification, as well as for evaluating in vitro drug-drug interactions.
Microsomes are produced by mechanically homogenising cells in a way that the endoplasmic reticulum is fragmented, the fractions of which reform into microsomes, which are subsequently collected from the cell remnants through differential centrifugation.