Pharmaceutical Business review

Summit Corp achieves milestones in SMT C1100 Phase 1

Following this achievement, Summit will receive the final payment from a $1.5m funding agreement with US based DMD organizations.

Summit chief executive officer Glyn Edwards said, "The funding will enable completion of the Phase 1 trial this year, after which we will seek an appropriate partner to advance SMT C1100 through proof-of-concept studies to ultimately bring this potential breakthrough therapy to patients with DMD."

SMT C1100 is a potential disease-modifying drug that works by increasing, or upregulating, the amount of a naturally occurring protein called utrophin.

Initiated in May 2012 in healthy volunteers, the Phase 1 dose-escalation study will now progress to the stage where participants receive multiple doses.

A group of US-based DMD organizations, which include the Muscular Dystrophy Association, Charley’s Fund, Cure Duchenne, the Foundation to Eradicate Duchenne, Nash Avery Foundation and Parent Project Muscular Dystrophy, supported the Phase 1 trial.

The company is expecting the results from the trial by the end of 2012.