Transposagen Biopharmaceuticals said academic, pharmaceutical, and biotech scientists use these animals for drug discovery and development research and are expected to be sold under its new TGEM Rat Models brand.
The new TGEM Rat Models include tumor suppressors, G protein-coupled receptors, and serotonin receptors. One showcase model is the Tumor Protein 53 (TP53) or p53 TGEM Rat Model.
Some other TGEM Rat Models include Rag1 – recombination activating gene 1 – immunodeficiency model, BCRP (aka Abcg2) – breast cancer resistance protein 1, Mc4r – melanocortin 4 receptor – obesity model, Ccr4 – C-C chemokine receptor type 4, Cxcr2 (aka IL8rb) – high affinity interleukin-8 receptor B or chemokine (C-X-C motif) receptor 2, IgE (aka Ighe) – Ig epsilon chain C region and GPR – over 100 different G Protein-Coupled Receptors.
Eric Ostertag, president and CEO of Transposagen Biopharmaceuticals, said: “A rat model lacking the function of this gene will be a tool for cancer biology and xenotransplantation studies.”