Fodosine (forodesine hydrochloride) is a transition state purine nucleoside phosphorylase (PNP) inhibitor, which functions by blocking the DNA synthesis machinery of the body’s T-cells. The small molecule drug
The target molecule, known as IKK (for IKappa kinase), regulates processes that can trigger dramatic changes in cellular physiology. Scientists have linked these changes to many different disorders.
Forty-four late-stage lung cancer patients who had not received prior chemotherapy were randomized to one of three groups for six months of treatment with the drug. The study
“This grant will expand the growing body of evidence of Talotrexin’s efficacy in combination with various novel cytotoxic and targeted therapeutic agents in arresting tumor growth,” said Dr
The phase I study is an open-label, dose-escalation study in up to 32 adults with hepatitis C; the objectives of the trial are to evaluate safety, pharmacokinetics and
Isis and Lilly will continue to advance antisense drugs identified during the previous collaboration, and continue their efforts to develop and refine antisense technologies. During the extension, Isis
The company has high hopes that alfimeprase will work more quickly and with fewer side effects than current industry standards, known as plasminogen activators, which can take several
The phase I dose-escalation trial is expected to enroll up to 46 healthy volunteers and is designed to collect safety and pharmacokinetic data. The funding of this clinical
BioFocus, a UK biotechnology company, will receive undisclosed fees from Organon for its role in the collaboration. The agreement is the second part of the company’s agreement with
“This will increase Merck’s presence in the world’s largest pharmaceutical market and will help solidify our position as the world’s third-largest global generics company,” said Hank Klakurka, CEO
Advertise With UsAdvertise on our extensive network of industry websites and newsletters.
Get the PBR newsletterSign up to our free email to get all the latest PBR
news.