The following case study details the measurement of a monoclonal antibody (mAb) in various formulation buffers, and with the addition of common excipients, to show the small variations in viscosity with concentration and excipient changes that the microcapillary flow technique is able to reliably measure.

The use of therapeutic antibodies is one of the fastest growing sectors for novel biopharmaceuticals, and the industry is under increasing pressure to deliver new therapies in a timely and safe manner.

Biopharmaceutical development processes are lengthy and complex with very specific analytical challenges, and particularly severely limited sample availability at the start of the pipeline.