Ruthenium(II) catalysts for asymmetric transfer hydrogenation reactions are often referred to as tethered catalysts because the chiral and arene ligand components are covalently linked, helping the chiral component to remain in the correct conformation, and preventing the arene component from rotating. This gives higher activity and stability to the transfer hydrogenation catalyst, making its performance much more similar to pressure hydrogenation catalysts, but without the need of specialized manufacturing equipment.

In particular, JMCCT tethered catalysts have proven applicable to traditionally difficult substrates such as alpha-chloroacetophenone, propargyl ketones and polyfunctionalized molecules, and also shown excellent results in other client applications.

Our series of ruthenium tethered catalysts include: