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news.Particle Sciences has announced the development of its microreservoir technology enabling the manufacture of drug-eluting polymer medical devices that release drugs at constant rates over 30 days or more.
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Particles Sciences said that this technology has already been used by the company to develop drug-eluting vaginal rings.
In their approach, Particle Sciences’s scientists first encapsulate the drug in polymer microparticles before blending with the polymer used to make the final product.
Particle Sciences sees broad utility for this proprietary technology, which is applicable to polymer devices, films, coatings and other polymeric structures from which drugs or other materials are to be released at a constant rate.
Robert Lee, vice president of pharmaceutical development at Particle Sciences, said: “Microencapsulating the drug enabled the use of simple molding processes to fabricate devices containing tens of thousands of microreservoirs, and the devices exhibit constant drug release profiles equivalent to traditional reservoir devices. This approach greatly simplifies production and adds tremendous flexibility to both single and multi-drug devices.”