Indevus’ Sanctura shows added bladder benefit

The researchers found that, when taken orally, trospium chloride not only helps control symptoms of overactive bladder systemically, but may also help control symptoms in the bladder itself when it comes into contact with the bladder walls.

In the study, urine samples from human subjects taking the anti-muscarinic drugs trospium, tolterodine LA and oxybutynin XL and from control subjects were instilled into the bladders of animal models.

Researchers induced bladder overactivity using carbachol. The trospium bladder did not react to the carbachol, indicating that the trospium had a topical effect on controlling the muscle contractions. In the control, tolterodine- and oxybutynin-treated bladders, the length of time between bladder contractions and the bladder’s capacity were decreased – representing overactive bladder-type conditions and indicating no topical effect.

“When taken orally, certain classes of drugs can control the muscle contractions that cause conditions like overactive bladder. In this study, we have found one drug, trospium, reacts with the bladder muscle as urine is stored in the bladder,” said Dr Michael Chancellor, professor in the department of urology at the University of Pittsburgh School of Medicine. “It is exciting to see that this drug could be helping the same patients in more ways than we had previously thought.”