Sirtris and National Cancer Institute collaborate in cancer research

The National Cancer Institute will test the compounds in well-established cancer cell lines which were previously used in the development of novel and existing chemo-therapeutics. The cell lines to be tested include some of the most common cancer types. The program will also test Sirtris’s compounds using in-vivo mouse tumor models to determine if the compounds reduce or limit the growth of the tumor cells.

The study will include SRT501, a proprietary formulation of resveratrol, and multiple compounds from different chemical classes of Sirtris’ new chemical entities, which are 1000 times more potent than resveratrol in in-vitro studies. All of the compounds activate SIRT1, an enzyme that has been shown to have anticancer properties in previous preclinical testing.