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C2N Diagnostics introduces new Alzheimer’s research tool

C2N Diagnostics has launched its new SILK-Aß, a commercial assay and research service for the measurement of neurally-derived biomolecules in vivo.

The SILK-Aß assay refers to the use of stable isotope labeling and tandem mass spectrometry for the measurement of the kinetics, or metabolism, of amyloid-beta. Amyloid-beta is a small peptide implicated as a key mediator of Alzheimer’s disease.

Joel Braunstein, managing member of C2N Diagnostics, said: “With the industry availability of this assay, for the first time, it is now possible for pharmaceutical and biotechnology companies to readily evaluate the impact of their development-stage compounds on the production and clearance rates of amyloid-beta.

The sensitivity of the assay intends to enable clinical researchers the ability to discriminate active from inactive drugs with a remarkably small number of patients.”