CSL Behring has begun Phase I/II study of subcutaneous administration of C1-esterase inhibitor in hereditary angioedema patients (HAE).
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The study, which will enroll adult patients with HAE type I or II, will estimate the safety, pharmacokinetics and pharmacodynamics of various doses of C1-INH.
CSL Behring clinical research and development senior vice president Russell Basser said, "Subcutaneous administration of C1-esterase inhibitor will represent another important advance for patients suffering from the frequent and often debilitating attacks of HAE."
The open-label study is a part of Clinical studies for Optimal Management in Preventing Angioedema with Low-Volume Subcutaneous C1-Inhibitor Replacement Therapy program.