DBV Technologies and Mount Sinai Hospital enter into research collaboration for Crohn’s disease

Crohn’s disease is a chronic condition for which there is currently no satisfactory cure able to increase the quality of life for people who have Crohn’s disease. DBV has already proven, in several pre-clinical studies that repeated epicutaneous immunotherapy (EPITTM) leads to increase natural and induced immune regulatory cells. Preliminary studies already showed that these immune regulatory cells play an essential role in by protecting the gut from inflammation.

DBV partnered with the Mount Sinai team, which has world-class expertise in cellular mechanisms involved in Crohn’s disease, having already demonstrated that administration of Tregs to patients with severe Crohn’s disease was well tolerated and efficacious.

DBV has established that Induction of immune regulatory cells can be achieved by epicutaneous exposure. The combination of DBV’s technology with Mount Sinai’s expertise could lead to a first-in-class approach to induce tolerance and decrease gut inflammation.

DBV Technologies chairman and CEO Dr. Pierre-Henri Benhamou noted Mount Sinai is a leading center in gastroenterology worldwide, at the forefront of Crohn’s disease research initiatives.

"We are extremely proud to contribute, along with Pr. Colombel and Dr. Dunkin, to a novel approach using Viaskin® in a severe condition, with no therapeutic alternative. We believe this new research area with such a center of excellence further emphasizes the potential of the Viaskin platform, positioning it as a technology enabling a deep and durable modulation of the immune system," Dr Benhamou added.