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news.Cytovance Biologics, a biopharmaceutical contract manufacturing company specializing in mammalian cell culture, has completed a collaboration with Invitrogen's PD-Direct Bioprocess Services.
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Cytovance Biologics has completed the process transfer and scale-up to 100L of a fed-batch bioreactor production process using Invitrogen’s new CD OptiCHO medium and CHO CD EfficientFeed supplement designed specifically for the fed-batch production process.
The project with Invitrogen was executed in Cytovance’s multi-product cGMP production facility in Oklahoma City. The 44,000 square feet facility meets the latest international regulatory standards and is custom-designed for efficient and cost-effective production.
This project involved a two-step scale-up from a shake flask process through two 5L bioreactor runs and then into production in the Cytovance cGMP 100L production facility using a recombinant CHO cell line producing approximately 1gm per liter.
John Lightholder, vice president of process science of Cytovance Biologics, said: “The completion of this development collaboration models the scientific competence we apply to all of our projects.”