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news.Senesco Technologies factor 5A-1 gene technology reduced inflammation and inhibited apoptosis in mouse experiments conducted at the University of Virginia School of Medicine.
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In these experiments, mice were pre-treated with Senesco’s small interfering RNA (siRNA) against factor 5A-1 and then challenged with LPS, which causes a classic systemic inflammatory response.
The factor 5A-1 pre-treated mice had significantly reduced blood levels of multiple pro-inflammatory cytokines.
Also of interest was that the cytokine IL-10, a down-regulator of pro-inflammatory cytokines, was unaffected by factor 5A-1, further enforcing that factor 5A-1 selectively recruits mRNAs for apoptosis and inflammation.
These data, in conjunction with the company’s previously reported data in which siRNA-treated mice had increased survival rates in the presence of lethal doses of LPS, indicate that siRNA to factor 5A-1 protects against premature cell death caused by inflammation.
“The down regulation of multiple pro-inflammatory cytokines in response to this siRNA administration is striking and encouraging for further studies. It will be of interest to study the cytokine response in more depth, especially when the siRNA is given after LPS,” commented Dr Michael Scheld, principle researcher in the trial.