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news.UK-based Mereo BioPharma Group has reported positive results of its Phase 1 drug interaction study with acumapimod, the active compound in its p38 MAP kinase inhibitor BCT-197.
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BCT-197 is currently in a Phase 2 study for the treatment of acute exacerbations of COPD (AECOPD).
This study evaluated potential drug interactions between acumapimod and the antibiotic azithromycin.
The study confirmed no drug interaction or evidence of adverse effects on safety and tolerability, meaning acumapimod may therefore be dosed with azithromycin.
Mereo chief medical officer Dr Alastair Mackinnon said: “We are delighted to announce the results of our Phase 1 drug interaction study. Patients with COPD frequently use azithromycin in the management of acute exacerbations and some use it as a maintenance therapy for their disease.
“The results of this study are encouraging as they remove restrictions on patients already taking azithromycin for the ongoing clinical programme and allow physicians to use this common antibiotic in the management of AECOPDs alongside BCT-197."