Mettler Toledo Presents Roller Compaction Process Optimisation

Mettler Toledo has presented roller compaction process optimisation using at-line particle characterisation, during the 2009 AAPS Annual Meeting, where the application of in situ particle characterisation was demonstrated to map the design space and optimise a series of roller compaction runs while varying raw materials, flow rates, and roller compaction forces.

According to the company, one goal of roller compaction is to improve compressibility and yield repeatable tablet dissolution and content uniformity. To ensure downstream process and product consistency, a successful roller compaction process establishes a continuous flow with a consistent particle size distribution.

However, inconsistencies often occur during dry granulation scale-up due to changing raw materials or process dynamics such as segregation, compaction force, and flow properties.

Additionally, in situ particle characterisation allows formulators or engineers to detect process upsets such as segregation and directly link process control parameters to the particle distribution. It enables formulators to ensure consistent product performance.

The company claims that by designing a roller compaction process, formulators and engineers can ensure consistent downstream processing from dry granulation through tablet compression.