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news.A newly developed time-released muco-adhesive patch OraMoist to treat oral health conditions, including dry mouth (xerostomia), has been shown to be more effective than an oral rinse, according to a newly-published study in the March 2010 issue of Quintessence International.
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The objective of the study was to assess a muco-adhesive lipid-based bioerodable patch as a novel device to decrease signs and symptoms associated with dry mouth, compared to an oral rinse.
The study involved 20 patients who suffered from dry mouth for more than three months as a result of medical conditions, who were divided into two treatment groups, oral rinse and muco-adhesive patch.
On the whole, patients with xerostomia treated with the muco-adhesive patch reported a major reduction in mouth dryness sensation with increased salivary flow rate (150%) after just 30 minutes, which was considered clinically outstanding by the authors of the study, owing to the fact that the product does not contain any cholinergic agonist, a drug often used to treat dry mouth. In addition, 70% of patients treated with the muco-adhesive patch reported they would continue using the product in the future, compared to only 30% who would continue using the leading mouthwash.
Quantum Health, a producer and marketer of natural OTC products, claimed that OraMoist would lubricate and moist the mouth with time-released lipids, citrus oil and sea salt, while simultaneously stimulating saliva production, and inhibiting bacterial growth and promoting oral health with enzymes and xylitol.
Abraham Domb, Professor at Institute of Drug Research, School of Pharmacy, Faculty of Medicine at the Hebrew University, and co-author of the new published study, inventor of the muco-adhesive time-released patch, said: “Oral disorders such as dry mouth and canker sores require long residence of the active remedy in the mouth or the disease site for effective treatment. Muco-adhesive patches made of safe ingredients that adhere to the oral mucosal tissue and slowly erode while releasing active remedies for two to six hours provide the desired residence time for effective therapy.
“This novel approach of time-released delivery has proven to be a successful and desirable approach to treating chronic conditions that affect millions of people, and can be disruptive to their lifestyle.”