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news.Pall Corporation (Pall) has introduced PallSep Biotech system for the gentle separation of target molecules from complex biotechnology process fluids. The new system utilises vibrating membrane filtration (VMF) technology and encapsulated hydrophilic polyethersulfone membrane filter modules.
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The company said that the combination reduces the accumulation of retained species on the membrane surface, which allows for increased transmission of the target molecule.
The PallSep Biotech system supports the production of high value products like therapeutic vaccines and antigen extracts. It permits the concentration, clarification and purification of feed streams with high levels of biomass particulates and viscosity, along with difficult-to-filter solutions such as fermentation broths and lysates.
PallSep Biotech system can be operated manually or within an automated process. It includes all valves, pumps, sensors, vessel and piping elements in a process system. GMP requirements for biopharmaceutical processes are met without compromising ease of use, flexibility, cleanability, safety or operating costs.
Nathalie Pathier, TFF product manager of Pall Life Sciences, said: “The new PallSep Biotech system expands processing options by allowing users to combine different process steps such as harvest and clarification within the same system, thus simplifying the process design. The stable permeate flow and improved protein transmission we can achieve with this technology contribute to better process economics.”