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news.Roche has announced that the combination of Tecentriq (atezolizumab) and Avastin (bevacizumab) plus chemotherapy (carboplatin and paclitaxel) has extended the life of patients with previously untreated advanced non-squamous non-small cell lung cancer (NSCLC) in the Phase III IMpower150 study.
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The study demonstrated that the Tecentriq combination has more effectively reduced the disease progression in patients compared to those who received Avastin plus chemotherapy.
IMpower150 is a multicenter, open-label, randomized and controlled study designed to assess the efficacy and safety of Tecentriq in combination with chemotherapy with or without Avastin in people with stage IV or recurrent metastatic non-squamous NSCLC.
The company had recruited 1,202 patients, of which those with ALK and EGFR mutations were excluded from the primary ITT analysis.
The patients have been randomized in 1:1:1 ratio to secure Tecentriq plus carboplatin and paclitaxel, Tecentriq and Avastin plus carboplatin and paclitaxel and Avastin plus carboplatin and paclitaxel.
According to the company, the co-primary endpoints were progression-free survival and overall survival, which were determined by the investigator.
Roche chief medical officer and global product development head Dr Sandra Horning said: “This Tecentriq study is the first positive Phase III combination trial that showed a cancer immunotherapy reduced the risk of the disease getting worse when used as an initial treatment in a broad group of people with advanced non-squamous NSCLC.
“The IMpower150 study represents an important advance in lung cancer treatment, and we will submit these results to regulatory authorities around the world to potentially bring a new standard of care to people living with this disease as soon as possible.”