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news.Sigma-Aldrich's manufacturing and services business unit, SAFC, is introducing a novel CHOZN GS Zinc Finger Nuclease (ZFN)-modified Chinese Hamster Ovary (CHO) cell line, for production of biopharmaceuticals.
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The new cell line which is glutamine synthetase (GS) knockout CHO cell line shortens bioproduction times in early development, improving the speed-to-market and cost efficiency.
CHOZN GS has been developed using SAFC’s proprietary CompoZr ZFN technology that inactivates the glutamine synthetase gene rendering the cells dependent on L-glutamine.
The parental cell line is cGMP banked using Animal Component Free (ACF), Chemically Defined (CD) media and has extensive viral testing, the company said.