Takeda, Millennium Initiate Phase II Trial For TAK-700

Takeda and its wholly-owned subsidiary, Millennium Pharmaceuticals have initiated stage II of a phase I/II clinical trial of TAK-700 in patients with advanced prostate cancer.

TAK-700 is a non-steroidal androgen synthesis inhibitor that, in preclinical studies, has been shown to selectively bind to and inhibit the enzyme 17, 20 lyase1 in both the testes and adrenal glands, suppressing the production of androgen.

Reportedly, the open-label, multiple-dose study will examine the safety and effectiveness of TAK-700 in patients with chemotherapy-naive metastatic castration-resistant prostate cancer.

The primary endpoints of the study are safety and tolerability with secondary measures to include efficacy, pharmacokinetic and pharmacodynamic endpoints.

Nancy Simonian, CMO at Millennium, said: “Our efforts in the development of drugs for prostate cancer represent a high-priority for Millennium. TAK-700 is the first drug candidate in our prostate program to advance to phase II clinical trials. We are pleased to see the progress of this compound, and we are striving to develop drugs that will fulfill the unmet medical need for prostate cancer.”