Appliflex

The AppliFlex single use bioreactor.

AppliFlex is the single use bioreactor range designed by Applikon. Manufactured according to the highest quality standards and backed by 35 years of bioreactor and sensor experience, an accurate measurement and control of important parameters is guaranteed. The combination of the bioreactor with sensors and control system offers great opportunities for cGMP applications.

The Appliflex bioreactor range consists of a 10L, 20L and 50L bioreactor bag. The bag and sensors (pH, DO, T) are designed for single-use. Optionally a re-usable sensor set can be used. The AppliFlex Rocker is designed in compliance with CE guidelines. It can be applied for a range of reactor volumes. The control system (pH, DO, T, rpm) is formed by the standard Applikon ez-Control.

Features of the Appliflex:

• Real time measurement of pH, DO, T, rocking speed
• Classic sensor measurement of pH, DO
• Fluorophores sensor measurement pH, DO
• Accurate control of pH, DO, T, rocking speed
• Data logging & SCADA (21CFR part 11) available
• Validatable system (total)
• Qualified support and service
• Total volume 10L, 20L, 50L
• Oxygen transfer increased by increasing the rocking rate and the angle of the bioreactor bag
• Lower shear stress levels than in stirred cell culture bioreactors

Applications

• Cell cultivation
• Batch and perfusion cultivation