BioSep

Retention system for perfusion, concentration and washing.

The Applikon BioSep system is a unique, cell retention device for high-density perfusion processes. Using high frequency resonant ultrasonic waves to separate cells instead of a physical mesh or membrane, it offers all the benefits of traditional devices but without their inherent problems and limitations.

The BioSep, based on the technology of acoustic resonance, is a non fouling / non clogging retention system. It can be applied in continuous mode which makes the BioSep the most favourable instrument for perfusion cultures. The BioSep can be applied in both R&D (max. 1L/day), process development and in production scale processes (1000L/day). Screening of cells and medium optimalisation typically are applications in the R&D segment. Furthermore the BioSep can be seen as the first step in the DownStream Processing. The technology of the BioSep also is very attractive for applications such as concentration of cell / particles and washing (e.g. beads).

Features, advantages and benefits:

• Proven under cGMP conditions
• Cost effective
• Easy to install and to operate
• Applicable on any type and brand of bioreactor
• Long term cultivation possible (>60 days)
• No fouling or blocking
• No damage to the cells
• Increased cell viability
• High separation efficiency