A novel High Content Assay to accurately plot and quantify each individual sub phase of DNA replication and mitosis by tracing endogenous PCNA protein in real time in living cells.
ChromoTek’s powerful Cell Cycle Chromobody® enables you to screen for compounds such as cancer drugs for effects on the cell cycle and toxicity in one experiment. You can apply this HCA assay in early drug development and validation as well as in basic research.
For simultaneous read out of:
- Cell size and morphology
- Nuclear morphology
- Progression of S phase with detailed detection of early-mid-late S phase
- Mitosis
Features of Cell Cycle Chromobody
- Trace dynamic changes during the cell cycle in real time
- Monitor the distribution of an endogenous cell cycle marker protein – in comparison to fluorescent fusion proteins no over expression artifact or cytotoxic effects
- Does not affect cellular functions
- Available as stable fluorescent HeLa and U2OS cell lines ready to go for cellular screening
- Available as plasmid to allow working with cell line of your choice
Cell Cycle Chromobody – Time series of a complete cell cycle.
Please contact us regarding the Cell Cycle Chromobody® cell lines and plasmid.
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