Disease Models, In Vivo PK, and Safety Pharmacology and Toxicology

Disease models

• Cardiovascular and metabolic diseases, diabetes, oncology, dermatology, gastrointestinal diseases and CNS models (e.g. Alzheimer’s and Parkinson’s, stroke and epilepsy)

In vivo PK

• Available species are rat, mouse, dog, rabbit and guinea pig
• Formulation for dosing (vehicle finding and vehicle stability)

Safety pharmacology and toxicology

• Modified Irwin test in mice and rats
• Locomotor activity
• Anti and pro-convulsant activity
• Analgesic activity
• Motor coordination
• BP and HR with telemetry
• Pulmonary functions and whole body plethysmography

In vivo disease models

We have more than 30 in vivo disease models, including:

• Tail-transection bleeding time test
• Renal / urinary system
• Gastrointestinal safety
• Toxicity screening and maximum tolerated dose
• GLP in vitro toxicology assays
• GLP in vivo toxicology assays, including respiratory toxicity