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Dnmt1 Chromobody®

Visualize DNA methylation pattern and trace the essential player of the epigenetic network that controls gene expression

DNA methylation is a crucial part of normal organism development and cellular differentiation in higher organisms. DNA methylation stably alters the gene expression pattern in cells such that cells can "remember where they have been" or decrease gene expression; for example, cells programmed to be pancreatic islets during embryonic development remain pancreatic islets throughout the life of the organism without continuing signals telling them that they need to remain islets.

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Dnmt1-Chromobody – Still images of Dnmt1-Chromobody® transfected HeLa cells throughout the cell cycle.

Dnmt1, the major eukaryotic DNA methyltransferase faithfully maintains genome-wide methylation patterns and plays an essential role in controlling gene expression and genome stability during development. The Dnmt1-Chromobody® comprises the antigen binding domain (VHH) derived from Alpaca heavy chain antibodies genetically fused to TagRFP or TagGFP2 (Evrogen).

Use the Dnmt1 Chromobody® to:

  • Visualize and study endogenous protein Dnmt1 in real time
  • Screen for inhibitors/activators of Dnmt1

Please contact us regarding the Dnmt1 Chromobody® plasmid.

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