Featured Applications

Our breakthroughs and innovations have made New England Biolabs a partner of choice for many leading biotech and pharma companies. Highlights of recent innovations include:

Accelerating Biological Drug Production

Rapid PNGase F completely removes N-glycans from antibodies and fusion proteins in 10 minutes or less, offering the potential to accelerate the quality control analysis of antibody-based therapeutics production. Additionally, we offer a diverse selection of highly-pure recombinant exo-glycosidases that better the structural characterization of glycans on biologics and biosimilars and offer creative options for the "glycoengineering" of cells or proteins.

Supporting the Development of mRNAs as Novel Therapeutics

NEB® offers a broad selection of reagents for mRNA synthesis. Featured products include the HiScribe™ T7 ARCA mRNA Kits, for rapid synthesis of capped and tailed full-length mRNAs for a variety of applications, including their use as candidate therapeutic agents. When you are ready to scale up, NEB is capable of supplying bulk reagent components in customized formats with the quality and documentation necessary to meet your needs.

Enabling The Next Generation of Testing in Clinical Trials

The success of techniques such as next-generation sequencing, microarrays and library construction is contingent on precise and accurate processing of DNA and RNA. The NEBNext® suite of products streamlines NGS sample preparation workflows, with improved yields, using minimal input amounts. Featured products include the NEBNext Ultra II DNA Library Prep Kit for Illumina, which delivers the highest library yields with as little as 500 pg input DNA, and the NEBNext FFPE DNA Repair Mix, which repairs multiple types of damage that are common among FFPE samples, improving yields and overall library success rates.

Exploring new drug targets

NEB supplies several products useful in the development and exploration of new drug targets. For example, the ordered assembly of multiple DNA sequences has grown in importance as researchers, including synthetic biologists, look for novel ways to create new and useful functionalities. To simplify this process, techniques such as NEBuilder® HiFi DNA Assembly create many functional DNA structures, from a simple joining of two metabolic genes potentially all the way up to the creation of an artificial genome. NEB also supplies a broad range of products that can be used in genome editing workflows, including sgRNA construction and mutation detection. The most recent addition to this product line includes recombinant Cas9 Nuclease with nuclear localization sequence.