Markush IP

Enabling Markush structures and patent/IP consideration during discovery, IT platform integration and computational chemistry research.

Patent search and combinatorial chemistry using Markush structures

A Markush structure is a description of a compound library by generic notations, primarily used in patent claims and for the description of combinatorial libraries. ChemAxon’s Markush enumeration calculator plugin and Markush search add-on together simplify the analysis of complex Markush structures and can represent and analyse the chemistry space described by generic Markush structures. With the recent addition of Markush DARC file format import, now it is possible to handle records from the Merged Markush Service (MMS) patent database of Thomson Reuters.

Markush Enumeration

The Markush enumeration plugin can be used to generate a whole or a subset of the Markush library. It is also capable of estimating the total number of specific structures present in a Markush library.

The plugin handles the following Markush features: R-groups, atom and bond lists, link nodes, repeating units, position variation bonds and homology variation.

Markush Search Add-on

Markush Search is an add-on to JChem Base and Instant JChem and allows the chemical structure searches of generic structures in a Markush table even without enumeration of Markush structures. The add-on includes Markush Enumeration calculator plugin too and it is available as web services.