Metabolism Studies, Drug Interaction Studies and Bioanalytical Services

Metabolism studies

• Metabolite profiling and identification: biotransformation and structural analysis in vitro and in vivo
• Metabolic stability, profiling and kinetics in vitro and in vivo
• Identification of rate-limiting CYP enzymes in vitro
• Various liver and other organ preparations available in eight species

Drug interaction studies

• CYP inhibition: cocktail study in microsomes or in hepatocytes
• CYP induction: nuclear receptor activation or cocktail studies in hepatocytes
• Identification of rate-limiting CYP enzymes

Bioanalytical services

• Bioanalytical method development and validation
• Quantitative bioanalysis from plasma / serum, urine or tissue
• Metabolite profiling and identification