Polymorph Screening

Polymorphic forms of a drug substance can have different chemical and physical properties, including melting point, chemical reactivity, apparent solubility, dissolution rate, optical and mechanical properties, vapour pressure and density. These properties can have a direct effect on the ability to process and/or manufacture the drug substance and the drug product, as well as on drug product stability, dissolution, and bioavailability.

Thus, polymorphism can affect the quality, safety, and efficiency of the final product.

PolyCrystalLine provides customized "hand-made" crystallization experiments for the polymorph quest, such as the choice of solvent, solvent mixture, temperature, support media and slurry interconversion.