Saturated organotrifluoroborates are crystalline bench stable solids used in the standard and photoredox-accelerated Suzuki-Miyaura reaction as well as other transition-metal-catalyzed cross-couplings. One of the recent trends in the field of organoboron reagents is related to the shift from aromatic compounds towards cyclic F(sp³)-enriched structures, which comply with criteria of lead-oriented synthesis. Increasing the number of C(sp³)-hybridized carbons is a way to make a compound more drug-like. In this context, Enamine offers a library of saturated organotrifluoroborates for metal-mediated couplings.

We offer >50 of aliphatic trifluoroborates from stock on a 5-10g scale.

Design and full list you can find at MedChem Highlights section of Enamine’s website or in the white paper attachment.