Selective incorporation of deuterium into organic molecules can profoundly alter their physical, chemical and biological properties.
Compared to hydrogen,deuterium displays a smaller molar volume (by 0.140 cm3/mol per atom), is less lipophilic (Δ logPoct = – 0.006) and might display a slightly different pKa. More importantly, C-D bonds are shorter (by 0.005 Å) and at times more stable to oxidative processes. This helps protect deuterated compounds from enzymatic degradation in the liver, increasing the compound’s half-life. In this context, Enamine offers a library of deuterium-containing building blocks for drug design.
We offer deuterium-containing building blocks from stock on a 5g-10g scale.
Design and full list you can find at MedChem Highlights section of Enamine’s website or in the free white paper download.