Diazirines for Photoaffinity Labeling Diazirine is the smallest heterocycle that is stable in the dark but forms reactive carbene upon irradiation with light. The formed carbenes smoothly insert into C-H, N-H, and O-H bonds.

Therefore, diazirines are often used as photoreactive crosslinking reagents due to their small size, a short period of irradiation, and stability toward nucleophiles. In this context, Enamine offers a library of diazirines for drug design.

We offer more than 100 diazirines from stock on a 5-10 g scale.

Design and full list you can find at MedChem Highlights section of Enamine’s website or in the white paper attachment.