Fluorinated derivatives play an important role in medicinal chemistry. The selective incorporation of a fluoroalkyl group into bioactive compounds often affects their binding affinity, metabolic stability, lipophilicity, membrane permeability and bioactivity. gem-difluoromethylene group (CF₂) is a valuable fluorinated motif that is present in pharmaceuticals and biologically active compounds. In particular, gem-CF₂-group improves ADME- and PK-properties. In this context, Enamine offers a library of unique difluoro-substituted cyclic amines for drug design.

We offer:

>100 gem-difluorinated amines on gram-scale from stock.

Design and a full list of compounds you can find at our web-page in MedChem highlights section or by downloading the attached white paper.