The organic chemistry of the pentafluorosulfanyl group (SF₅) has been known since the 1950s. As the SF₅-group is larger and more lipophilic than the CF₃-one, it is often considered as a ‘super-trifluoromethyl group’. Over the past decade, the SF₅–containing organic compounds already found great practical application in argochemistry and medicinal chemistry.

Properties

• One of the most electron-withdrawing groups
• high chemical and thermal stability
• high lipophilicity

Our offer

> 30 SF₅-buiding blocks in gram amounts in stock. Custom synthesis of analogues and compound libraries