The oligonucleotide therapeutics field has seen remarkable progress over the last few years. The first antisense drug was approved and clinical trials using small interfering ribonucleic acid (siRNA) or splice switching oligonucleotide show promising developments.
The analytical separation of oligonucleotides and their purification following synthesis require special considerations. These have been traditionally met by anion exchange chromatography.
Specifically designed resins offer high-resolution and selectivity, as well as allow specific oligonucleotide extraction, analysis, purification and polishing.
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